CENTER FOR TUBERCULOSIS RESEARCH

PROFILE

The Center for Tuberculosis Research (CTBR) is a unique collaborative Research Center in the Department of Microbiology of the Nigerian Institute of Medical Research. The first National Tuberculosis Reference Laboratory in Nigeria is domiciled within this Center.

The CTBR contributes to the WHO End TB Strategy programme through research, service and training. CTBR conducts a range of multi-disciplinary research and training by dedicated scientists and support staff in collaboration with universities, public and private sector organizations within the sub region and internationally.

Research

Current research focus is on tuberculosis (TB) epidemiology, drug resistance, evaluation of novel diagnostics and laboratory management of MDRTB patients. Current research is supported by the Nigerian Government (Nigerian Institute of Medical Research and International organization (West African Node of Excellence for TB, AIDS and Malaria [WANETAM]. We also access grants for our research activities.

Research Team:

CTBR has sixteen Research Staff comprising of four Research Scientists, five Laboratory Scientists, three Laboratory Technologists, one Scientific Officer and three adhoc scientists that carry out research activities in the Center. The center also has on its research team, an adjunct professor of research in the person of Prof Simon Cadmus of the University of Ibadan.

S/N    NAME                                                  DESIGNATION

RESEARCH FELLOW

1.  Mrs. C. N. Kunle – Ope                        Research Fellow II/Head

2.  Dr. N. N. Onyejepu                               Senior Research Fellow

3.  Dr.(Mrs.) O.F. Davies-Bolorunduro     Research Fellow I

4.  Mrs. I. T. Ndubuisi                               Research Fellow II

MEDICAL LABORATORY SCIENTIST

5.  Mrs. M. A. A. Adetunji                        Chief Medical Laboratory Scientist

6.  Mrs. N. E. Tochukwu                           Chief Medical Laboratory Scientist

7.  Mr. A. A. Adesesan                              Chief Medical Laboratory Scientist

8.  Rev. Sr. C. O. Ejezie                             Asst. Chief Medical Laboratory Scientist

9.  Mr. Samuel Nduaga                             Chief Medical Laboratory Scientist

SCIENCE LABORATORY SCIENTIST

10.  Mrs. I.O Edu-muyideen                        Chief Science Laboratory Technologist

11.  Mrs. A. T. Abiodun                              Science Laboratory Technologist 1

SCIENTIFIC OFFICER

12.  Mrs. B.O. Acholo                                 Scientific Officer II

13.  Mr. G. R. Lawal                                    Scientific Officer II

ADMINISTRATIVE STAFF

16.  Mr. D. Airekhome                                 Administrative Officer

17.  Mrs. C. J. Alaribe                                  Clerical Officer I

18.  Mrs. L. Allen                                        Clerical Officer I

ADHOC STAFF

19.  Mr. K. Atoe                                          Senior Programme Officer (IHVN )

PROJECT STAFF

20.  Mrs. C. Okorie                                      Medical Laboratory Scientist

21.  Mr. S. Audu                                          Data Officer

22.  Ms. H. L. Ibrahim                                 Data Officer

SUPPORT STAFF

23.  Mrs. J. Elijah                                         Cleaner

 


 

In 2019, CTBR created two research groups to improve research output from the Division namely:

Mrs. Kunle-Ope C.N.

(Contact: chiomakunleope@gmail.com; cnkunle-ope@nimr.gov.ng) – Heads the TB Diagnostic & Epidemiology Research that conduct research into:

  • Sentinel surveillance of TB
    • Characterizing, tracking trends and profile of Mycobacterium tuberculosis Complex (MTBC) including Mycobacterium bovis and Non-tuberculous mycobacteria (NTM).
  • TB Epidemiology
    • Molecular epidemiology of TB
    • Genetic diversity of TB
  • Research on diagnostic and monitoring tools
    • Method verification and comparison of diagnostic laboratory methods
    • Evaluation of novel diagnostics

Dr Davis-Bolourunduro O.F.  (Contact: bizdave1@gmail.com; of.davies-bolorunduro@nimr.gov.ng)  – Heads the TB Drug Resistance and Pharmocogenomics Research Group that conduct research into:

  • Drug resistance of mycobacteria
  • Antimycobacterial natural products
  • Pharmocogenomics

 Research Achievement

  • Diagnosis of TB and Management of Paediatric TB (EDCTP-WANETAM Grant)
  • Bioprospecting for Antituberculous Potentials of Culturable Marine Actinomycetes from Lagos Lagoon Sediments
  • Molecular Epidemiology of TB
  • Study on the Evaluation of Respiratory Tract Bacterial Co-infections with COVID-19 Severity in Lagos, Nigeria

Ongoing Research

  • Desk Review with Whole Genome Sequencing of Mycobacterium Tuberculosis
  • Correlation of Clinical Outcomes of Patients on Anti Tuberculosis Regimen
  • Exploration of Marine Bacterial Community Genomics in Nigeria Coastal Waters for Prospective Novel Drugs and Bio-pharmaceutics (In Collaboration with Microbiology Department, University of Lagos)
  • Sequencing of Drug Resistant TB (REST HUB) Project – CTBR (In collaboration with IHVN
  • Whole Genome Sequencing for Investigating Mycobacterium Tuberculosis Transmission, Genetic Diversity and Multi-Drug Resistance Prediction in Lagos, Nigeria – CTBR (In Collaboration with Redeemer University)
  • Genomic Information Surveillance on Drug-resistant Mycobacterium tuberculosis Isolates from Nigeria/TB-Portal – CTBR (In Collaboration with Adjunct Professor)
  • Transposing multidrug-resistant M. tuberculosis molecular and genomic epidemiology to Public Health and Product Development in Nigeria (In Collaboration with University of Lisbon, Portugal)
  • Susceptibility Testing of Delamanid and Bedaquinine using BACTEC MGIT 960 – CTBR (In collaboration with IHVN)
  • Smart Detection of MTB Using Artificial Intelligence & Microscopy (In Collaboration with Redeemer University)

 Grant Awards

  • WANETAM-3 Grant – Dr. Onyejepu N.

Laboratory services: National Tuberculosis reference Laboratory

The Center offers diagnostic services for pulmonary and extra-pulmonary TB using both conventional and molecular methodologies under quality management system, good clinical and laboratory practice (GCLP). The CTBR is equipped with biosafety level 2 and 3 laboratories and a molecular diagnostic suite. We also prepare quality panels for public and private laboratories on TB microscopy and GeneXpert. Our service is supported by the Nigerian Government (National Tuberculosis and Leprosy Control Programme), implementing partners (Institute of Human Virology, Nigeria) and Tuberculosis Supra Reference Laboratory, Milan, Italy, Tuberculosis Supra Reference Laboratory, Antwerp, Belgium and Tuberculosis Supra Reference Laboratory, Cotonou, Benin.

In November 2019, CTBR obtained international accreditation; ISO15189 by South Africa National System (SANAS) on TB Microscopy and PCR-TB Identification and Drug Susceptibility Tests (GeneXpert and Hain). In January 2022, the Centre was recommended for further accreditation of TB Culture and Drug Susceptibility Testing Services by SANAS.

 

PRICE LIST FOR TB TEST

S/NTESTPRICE (₦)
DIAGNOSIS USING CONVENTIONAL METHODS
1Sputum Smear Microscopy using Ziehl Nelsen (ZN) Stain5,000.00
2Sputum Smear Microscopy using Fluorescence (FM) Stain5,000.00
3Sputum Smear Microscopy and Culture on Solid Media (Lowenstein Jensen)10,000.00
4Sputum Smear Microscopy and Culture on Liquid Media (MGIT BACTEC 960 TB System) Only30,000.00
5Sputum Smear Microscopy, Culture and Drug Susceptibility Testing (DST) on Solid Media (Lowenstein Jensen) for First Line Drugs using Proportion Method25,000.00
6Sputum Smear Microscopy, Culture and Drug Susceptibility Testing (DST) on Solid Media (Lowenstein Jensen) for First and Second Line Drugs using Proportion Method30,000.00
7Sputum Smear Microscopy, Culture and Drug Susceptibility Testing (DST) in Liquid Media (MGIT BACTEC 960 TB System) for First Line Drugs Only40,000.00
8Sputum Smear Microscopy, Culture and Drug Susceptibility Testing (DST) in liquid media (MGIT BACTEC 960 TB System) for First and Second Line Drugs50,000.00
DIAGNOSIS USING MOLECULAR METHODS
9Diagnosis of TB and Detection of resistance to Rifampicin from Sputum/Stool Samples using GeneXpert10,000.00
10Diagnosis of TB and Detection of resistance to First Line Anti-TB Drugs (Rifampicin and Isoniazid) using Hain GenoType MTBDRplus (Line Probe Assay) Only30,000.00
11Diagnosis of TB and Detection of resistance First Line (Rifampicin and Isoniazid) and Second Line (Fluoroquinolones and Aminoglycosides) Anti-TB Drugs using Hain GenoType MTBDRplus (Line Probe Assay)60,000.00
12Species identification of Mycobacterium tuberculosis and other mycobacteria other than Mycobacterium tuberculosis using Hain GenoType CM/AS (Line Probe Assay)30,000.00
13Quality Panel Preparation for AFB Microscopy & GeneXpertSubject to negotiation

Data Purchase

Data purchase will depend on the number of data units and length (months or years) of the data duration needed. The Data can be collected from a minimum period of 6 months to a maximum of 5 years.

All associated demographic data (Sex, Age, etc.) will not be charged.

NB: Cost of a data request will be based on the sample size multiplied by the unit price with 10% concession for data more than 1 year.

 

S/NDATAUNIT PRICE BULK PRICE (6 MONTH – 5YRS)
1.Data on GeneXpertN500Sample Size x Unit Price
 Data on AFB MicroscopyN 100Sample Size x Unit Price
3.

Data on

First-line LPA

Second line LPA

Both first and second-line LPA

 

N1000

N2000

N2000

 

Sample Size x Unit Price

Sample Size x Unit Price

Sample Size x Unit Price.

4.

Data on Culture & DST

First-line drugs

Second-line drugs

Both first and second-line drugs

 

N1000

N2000

N2000

 

Sample Size x Unit Price

Sample Size x Unit Price

Sample Size x Unit Price

 

Biorespository

The Center has characterized mycobacterial collections in her bio-repository.

 

Training

The Center utilizes its facilities for training of research scientists, and other organizations involved in MTBC and other mycobacteria projects. We provide training on the following:

  • Diagnosis, Treatment and Conduct of Research on MDR-TB
  • Advanced Tuberculosis Research for Health Professionals and Post Graduate Students
  • Establishing and Maitaining Quality Assured Services for Public and Private Health Practitioners

We also provide bench training for students on Internship and Industrial Training

  • AFB Microscopy using light and fluorescence microscope
  • GeneXpert
  • Line Probe Assay (LPA)
  • Culture & Drug Susceptibility Testing (DST) using solid (Loweinstein Jenseen media) and liquid (BACTEC MGIT 960 System)
  • MIRU-VNTR Typing

 

Contact us @

Phone Number: +234 909 384 5605, +234 809 700 9975

E-mail: ctbr.micro@nimr.gov.ng

KUNLE-OPE CHIOMA NNEKA

HEAD/LABORATORY MANAGER, CTBR

Mrs. A. T. Abiodun

STAFF OF THE MONTH OF JUNE, 2022
(For job performance, Team spirit & promptness to TAT of on-going TRIAD Project)

STAFF OF CENTRE FOR TUBERCULOSIS RESEARCH

Biosafety Level 3 Laboratory Suite

Sample Processing Room in Biosafety Level 3 Laboratory Suite

Sample Processing Room in Biosafety Level 2 Laboratory Suite

GeneXpert Room in Biosafety Level 2 Laboratory Suite

Molecular Suite for Molecular Diagnosis of TB

GeneXpert Room in Biosafety Level 2 Laboratory Suite