CENTER FOR TUBERCULOSIS RESEARCH

PROFILE

The Center for Tuberculosis Research (CTBR) is a unique collaborative Research Center in the Department of Microbiology of the Nigerian Institute of Medical Research. The first National Tuberculosis Reference Laboratory in Nigeria is domiciled within this Center.

CTBR contributes to the national tuberculosis (TB) elimination programme through research, service, and training. At the Center, we conduct a range of multi-disciplinary research and training in collaboration with universities, public and private sector organizations within the sub region and internationally. Current research focus is on TB epidemiology, drug resistance, evaluation of novel diagnostics and laboratory management of multi drug resistance tuberculosis (MDRTB). Our research is supported by the Nigerian Government (National Tuberculosis and Leprosy Control Programme), implementing partners (Institute of Human Virology, Nigeria and FHI 360) and International organizations (West African Node of Excellence for TB, AIDS and Malaria [WANETAM] and Tuberculosis Supra Reference Laboratory, Milan, Italy). We also access grants for our research activities.

In addition, CTBR is equipped with biosafety level 2 and 3 laboratories and a molecular diagnostic suite. The Center offers programmatic diagnosis of pulmonary and extra-pulmonary TB using both conventional and molecular methodologies under quality management system and good laboratory and clinical practices. The Center also utilizes its facilities for training of research scientists, students and other organizations involved in TB elimination. In November 2019, CTBR obtained ISO 15189 accreditation by South Africa National Accreditation System in TB Microscopy, PCR TB Identification and Drug Susceptibility Tests (GeneXpert and Hain).

Research Team:

CTBR has sixteen scientific staff members comprising of four research scientists, five laboratory scientists, three laboratory technologists, one scientific officer and three adhoc scientists that carry out research activities in the Center. The Center has two research groups aimed to improve research output from the Centre namely:

  1. Tuberculosis Diagnosis and Epidemiology Research Group headed by Kunle-Ope C.N, is focused on the following research activities:
  • TB Diagnosis
    • Characterizing, tracking trends and profile of Mycobacterium tuberculosis Complex (MTBC) including Mycobacterium bovis and Non-tuberculous mycobacteria (NTM).
  • TB Epidemiology
    • Molecular epidemiology of TB
    • Genetic diversity of TB
  • Research on diagnostic and monitoring tools
    • Method verification and comparison of diagnostic laboratory methods
    • Evaluation of novel diagnostics
  1. Tuberculosis Drug Resistance and Pharmocogenomics Research Group, headed by Dr Davis-Bolourunduro O.F, is involved with the following research activities:
  • Drug resistance of mycobacteria
  • Antimycobacterial natural products
  • Pharmocogenomics

Completed Research Activities in year 2020 at the  CTBR

  • Research on mutation analyses of MDR-TB strains in collaboration with Public Health and Epidemiology Department, NIMR
  • Diagnosis of TB using Line Probe Assay (LPA) and phenotypic method in collaboration with Medical Microbiology and Parasitology Department, LUTH

Ongoing Research Activities in CTBR

  • MDR-TB Surveillance in collaboration with National TB and Leprosy Control Programme and Institute of Human Virology, Nigeria
  • Molecular Epidemiology of TB
  • WANETAM consortium of diagnosis of TB and management of children funded by EDCTP
  • Whole genome sequencing for investigation of Mycobacterium tuberculosis complex strain, diversity & MDR-TB resistance prediction in Nigeria, in collaboration with Redeemer University, Ede, Osun State
  • Smart detection of Mycobacterium tuberculosis using artificial intelligence & microscopy, in collaboration with Redeemer University, Osun State
  • Bioprospecting for Antituberculous Potentials of Culturable Marine Actinomycetes from Lagos Lagoon Sediments
  • Genomic Information Surveillance on Drug-resistant Mycobacterium tuberculosis Isolates from Nigeria/TB-Portal, in collaboration with our adjunct, Professor Cadmus and NHIS)
  • Evaluation of GeneXpert MTB/RIF for Detection of Mycobacterium tuberculosis and Resistance to Rifampicin among Presumptive TB Cases in Lagos State
  • Non-Tuberculous Mycobacteria Infections among Cases of Bronchopulmonary Disorder in Lagos State

Our TEAM

      NAME                                                           DESIGNATION                           

  • Mrs. C. N. Kunle – Ope                            Research Fellow 11/Head
  • Dr. N. N. Onyejepu                                   Senior Research Fellow
  • Dr.(Mrs.) O.F. Davies-Bolorunduro         Research Fellow I
  • Mrs. I. T. Ndubuisi                                    Research Fellow II

MEDICAL LABORATORY SCIENTIST

  • Mrs. M. A. A. Adetunji                             Chief Medical Laboratory Scientist
  • Mrs. N. E. Tochukwu                                Asst. Chief Medical Laboratory Scientist
  • Mr. A. A. Adesesan                                  Asst. Chief Medical Laboratory Scientist
  • Rev. Sr. C. O. Ejezie                                 Asst. Chief Medical Laboratory Scientist
  • Mr. Sunday Ogamde                                 Senior Medical Laboratory Scientist

 SCIENCE LABORATORY SCIENTIST

  • Mrs. I.O Edu-muyideen                            Chief Science Laboratory Technologist
  • Mrs. A. T. Abiodun                                   Science Laboratory Technologist 1

 SCIENTIFIC OFFICER

  • Miss B.O. Amuda                                     Scientific Officer II

 MEDICAL LABORATORY  TECHNICIAN

  • Mr. I.I. Garba                                            Medical Laboratory Technician

 ADMINISTRATIVE STAFF

  • Mr. O. O. Shopitan                                    Chief Clerical Officer
  • Mrs. L. Allen                                             Clerical Officer I

 ADHOC STAFF

  • Mr. K. Atoe                                               Medical Laboratory Scientist/Senior Programme Officer (IHVN )

 PROJECT STAFF

  • Mrs. C. Okorie                                           Medical Laboratory Scientist/IHVN HR Staff
  • Mr. S. Audu                                              Data Officer
  • Miss L.H. Ibrahim                                     Data Officer
  • Mr. O. Kokson                                          Biologist/FHI 360 Volunteer Staff

 SUPPORT STAFF

  • Mrs. J. Elijah                                             Cleaner
  • Mrs. R.O. Ogunfowoke                            Cleaner

 ADJUNCT RESEARCH PROFESSOR

  • Prof. S. I. Cadmus                                     University of Ibadan

 

PRICE LIST FOR TB TEST

S/N

TEST

PRICE (₦)

DIAGNOSIS USING CONVENTIONAL METHODS

1

Sputum Smear Microscopy using Ziehl Nelsen (ZN) Stain

5,000.00

2

Sputum Smear Microscopy using Fluorescence (FM) Stain

5,000.00

3

Sputum Smear Microscopy and Culture on Solid Media (Lowenstein Jensen)

10,000.00

4

Sputum Smear Microscopy and Culture on Liquid Media (MGIT BACTEC 960 TB System) Only

30,000.00

5

Sputum Smear Microscopy, Culture and Drug Susceptibility Testing (DST) on Solid Media (Lowenstein Jensen) for First Line Drugs using Proportion Method

25,000.00

6

Sputum Smear Microscopy, Culture and Drug Susceptibility Testing (DST) on Solid Media (Lowenstein Jensen) for First and Second Line Drugs using Proportion Method

30,000.00

7

Sputum Smear Microscopy, Culture and Drug Susceptibility Testing (DST) in Liquid Media (MGIT BACTEC 960 TB System) for First Line Drugs Only

40,000.00

8

Sputum Smear Microscopy, Culture and Drug Susceptibility Testing (DST) in liquid media (MGIT BACTEC 960 TB System) for First and Second Line Drugs

50,000.00

DIAGNOSIS USING MOLECULAR METHODS

9

Diagnosis of TB and Detection of resistance to Rifampicin from Sputum/Stool Samples using GeneXpert

10,000.00

10

Diagnosis of TB and Detection of resistance to First Line Anti-TB Drugs (Rifampicin and Isoniazid) using Hain GenoType MTBDRplus (Line Probe Assay) Only

30,000.00

11

Diagnosis of TB and Detection of resistance First Line (Rifampicin and Isoniazid) and Second Line (Fluoroquinolones and Aminoglycosides) Anti-TB Drugs using Hain GenoType MTBDRplus (Line Probe Assay)

60,000.00

12

Species identification of Mycobacterium tuberculosis and other mycobacteria other than Mycobacterium tuberculosis using Hain GenoType CM/AS (Line Probe Assay)

30,000.00

KUNLE-OPE CHIOMA NNEKA

HEAD/LABORATORY MANAGER, CTBR

CTBR STAFF OF THE YEAR 2020

They are recognized for their selfless service to the laboratory especially during the COVID-19 lockdown.

MS. AMUDA OYEWUMI BOSE

MRS. ABIODUN TEMITOPE ABIGAIL

STAFF OF THE MONTH OF JUNE, 2021

MR. STEVE ISHAYA AUDU

(For Job Performance, Team Spirit and Promptness to TAT)

STAFF OF CENTRE FOR TUBERCULOSIS RESEARCH

Biosafety Level 3 Laboratory Suite

Sample Processing Room in Biosafety Level 3 Laboratory Suite

Sample Processing Room in Biosafety Level 2 Laboratory Suite

GeneXpert Room in Biosafety Level 2 Laboratory Suite

Molecular Suite for Molecular Diagnosis of TB

GeneXpert Room in Biosafety Level 2 Laboratory Suite